Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor-Reference-Cited by-同舟云学术

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor

Published:2020-05-08 Issue:12 Volume:11 Page:1781-1790
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Crowley Rachel S.¹,Riley Andrew P.²,Alder Amy F.³,Anderson Richard J.³,Luo Dan¹⁴,Kaska Sophia¹⁴,Maynez Pamela¹,Kivell Bronwyn M.³,Prisinzano Thomas E.¹⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States

2. Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, United States

3. School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington 6140, New Zealand

4. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States

Funder

National Institute on Drug Abuse

National Institutes of Health

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00191

Reference40 articles.

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4. Centers for Disease Control and Prevention Prescription Opioid Data, https://www.cdc.gov/drugoverdose/data/prescribing.html (accessed January 27, 2019).

5. Institute of Medicine (US) Committee on Advancing Pain Research, Care, and Education (2011) Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. National Academies Press (US): Washington (DC).

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