Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model
Author:
Affiliation:
1. Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy
2. Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy
Funder
Università degli Studi di Brescia
Università degli Studi di Firenze
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00431
Reference68 articles.
1. Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
2. Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease
3. Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
4. Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot
5. Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease
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