Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective

Author:

Ong Han Wee1ORCID,Liang Yi1,Richardson William2,Lowry Emily R.34ORCID,Wells Carrow I.1ORCID,Chen Xiangrong2,Silvestre Margaux5ORCID,Dempster Kelvin5ORCID,Silvaroli Josie A.6,Smith Jeffery L.1,Wichterle Hynek34789,Pabla Navjot S.6,Ultanir Sila K.5,Bullock Alex N.2ORCID,Drewry David H.110ORCID,Axtman Alison D.1ORCID

Affiliation:

1. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

3. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, United States

4. The Project ALS Therapeutics Core, Columbia University Irving Medical Center, New York, New York 10032, United States

5. Kinases and Brain Development Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.

6. Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States

7. Departments of Neurology, Neuroscience, Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States

8. Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New York, New York 10032, United States

9. Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, New York 10032, United States

10. UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

Innovative Medicines Initiative

Canada Foundation for Innovation

North Carolina Biotechnology Center

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

National Institutes of Health

Eshelman Institute for Innovation, University of North Carolina

Structural Genomics Consortium

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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