Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates

Author:

Haider Ahmed12ORCID,Wang Lu3ORCID,Gobbi Luca4ORCID,Li Yinlong2,Chaudhary Ahmad2,Zhou Xin2,Chen Jiahui2ORCID,Zhao Chunyu2,Rong Jian2ORCID,Xiao Zhiwei2,Hou Lu3,Elghazawy Nehal H.5,Sippl Wolfgang5ORCID,Davenport April T.6,Daunais James B.6,Ahmed Hazem7ORCID,Crowe Ron2,Honer Michael4,Rominger Axel8,Grether Uwe4,Liang Steven H.2ORCID,Ametamey Simon M.7ORCID

Affiliation:

1. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, United States

2. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States

3. Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China

4. Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, 4070 Basel, Switzerland

5. Institute of Pharmacy, Department of Medicinal Chemistry, Martin-Luther-University Halle-Wittenberg, W.-Langenbeck-Str. 4, 06120 Halle, Germany

6. Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States

7. Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Institute of Pharmaceutical Sciences ETH, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland

8. Department of Nuclear Medicine, Bern University Hospital, 3010 Bern, Switzerland

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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