Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2
Author:
Affiliation:
1. Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, United States
2. Department of Pharmacology, School of Medicine, Emory University, Atlanta, Georgia 30322, United States
Funder
National Institute of Neurological Disorders and Stroke
Brain and Behavior Research Foundation
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.7b00486
Reference40 articles.
1. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.
2. Neuroprotective Function of the PGE2 EP2 Receptor in Cerebral Ischemia
3. Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia
4. Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus
5. EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia
Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Complementary roles of EP2 and EP4 receptors in malignant glioma;British Journal of Pharmacology;2023-06-28
2. Neuroinflammatory mediators in acquired epilepsy: an update;Inflammation Research;2023-02-06
3. Biological aspects of nitrogen heterocycles for amyotrophic lateral sclerosis;Applied Microbiology and Biotechnology;2022-12-08
4. Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma;Cell Reports;2022-06
5. EP2 Antagonists (2011–2021): A Decade’s Journey from Discovery to Therapeutics;Journal of Medicinal Chemistry;2021-08-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3