Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Author:
Affiliation:
1. Pharmaceutical Products Division, Abbott Laboratories, D-47D, AP52, 200 Abbott Park Road, Abbott Park, Illinois 60064
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm970636%2B
Reference56 articles.
1. Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.
2. An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity.
3. HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins
4. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.
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