Synthesis, Biological Evaluation, and Enzyme Docking Simulations of 1,5-Diarylpyrrole-3-Alkoxyethyl Ethers as Selective Cyclooxygenase-2 Inhibitors Endowed with Anti-inflammatory and Antinociceptive Activity-Reference-Cited by-同舟云学术

Synthesis, Biological Evaluation, and Enzyme Docking Simulations of 1,5-Diarylpyrrole-3-Alkoxyethyl Ethers as Selective Cyclooxygenase-2 Inhibitors Endowed with Anti-inflammatory and Antinociceptive Activity

Published:2008-07-04 Issue:15 Volume:51 Page:4476-4481
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Anzini Maurizio¹,Rovini Michele¹,Cappelli Andrea¹,Vomero Salvatore¹,Manetti Fabrizio¹,Botta Maurizio¹,Sautebin Lidia¹,Rossi Antonietta¹,Pergola Carlo¹,Ghelardini Carla¹,Norcini Monica¹,Giordani Antonio¹,Makovec Francesco¹,Anzellotti Paola¹,Patrignani Paola¹,Biava Mariangela¹

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Via A. Moro, 53100 Siena, Italy, Dipartimento di Farmacologia Sperimentale, Università di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy, IRCCS Centro Neurolesi ”Bonino-Pulejo”, Via Provinciale Palermo−C. da Casazza, I-98124 Messina, Italy, Dipartimento di Farmacologia Preclinica e Clinica “M. Aiazzi Mancini”, Università degli Studi di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy, Rottapharm S.p.A., Via Valosa di...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800084s

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4. Oxidative Metabolism of Endocannabinoids by COX-2

5. Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

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