Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors-Reference-Cited by-同舟云学术

Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors

Published:2008-05-15 Issue:11 Volume:51 Page:3154-3170
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Butini Stefania¹,Campiani Giuseppe¹,Borriello Marianna¹,Gemma Sandra¹,Panico Alessandro¹,Persico Marco¹,Catalanotti Bruno¹,Ros Sindu¹,Brindisi Margherita¹,Agnusdei Marianna¹,Fiorini Isabella¹,Nacci Vito¹,Novellino Ettore¹,Belinskaya Tatyana¹,Saxena Ashima¹,Fattorusso Caterina¹

Affiliation:

1. European Research Centre for Drug Discovery and Development (NatSynDrugs), Università di Siena, 53100 Siena, Italy, Dipartimento Farmaco Chimico Tecnologico, via Aldo Moro, Università di Siena, 53100 Siena, Italy Dipartimento di Chimica delle Sostanze Naturali e Dipartimento di Chimica Farmaceutica e Tossicologica Università di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy, and Division of Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701253t

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1. Alzheimer Disease in the US Population

2. Causative and susceptibility genes for Alzheimer’s disease: a review

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4. Cholinesterase inhibitors: new roles and therapeutic alternatives

5. Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment

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