Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Published:1998-02-28 Issue:2 Volume:2 Page:128-133
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Bruggink Alle¹,Roos Eric C.¹,de Vroom Erik¹

Affiliation:

1. Chemferm, P.O. Box 3933, 4800 DX Breda, The Netherlands, DSM Research, P.O. Box 18, 6160 MD Geleen, The Netherlands, and Gist-brocades B.V., P.O. Box 1, 2600 MA Delft, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op9700643

Reference58 articles.

1. An efficient nonenzymatic conversion of benzylpenicillin to 6-aminopenicillanic acid

2. One-step, high yield conversion of penicillin sulfoxides to deacetoxycephalosporins

3. Industrial transformations of penicillins and cephalosporins

4. Substrate specificity of immobilized penicillin-G acylase towards penicillin and cephalosporin derivatives was studied. The phenylacetyl moiety can be altered at the α-position with several small substituents. Depending on polarity and size of the substituent, enzyme activity decreases or increases. Insertion or deletion of atoms between the aromatic nucleus of the phenylacetyl group and the center of hydrolysis leads to substrates that are no longer recognized by the enzyme.

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