Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates-Reference-Cited by-同舟云学术

Strategies at the Interface of Drug Discovery and Development: Early Optimization of the Solid State Phase and Preclinical Toxicology Formulation for Potential Drug Candidates

Published:2010-06-08 Issue:16 Volume:53 Page:5897-5905
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Palucki Michael¹,Higgins John D.¹,Kwong Elizabeth¹,Templeton Allen C.¹

Affiliation:

1. Basic Pharmaceutical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1002638

Reference39 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

2. Profiling drug-like properties in discovery research

3. Property-Based Design: Optimization of Drug Absorption and Pharmacokinetics

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