Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase-Reference-Cited by-同舟云学术

Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Published:2007-03-21 Issue:9 Volume:50 Page:2213-2224
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mortlock Andrew A.¹,Foote Kevin M.¹,Heron Nicola M.¹,Jung Frédéric H.¹,Pasquet Georges¹,Lohmann Jean-Jacques M.¹,Warin Nicolas¹,Renaud Fabrice¹,De Savi Chris¹,Roberts Nicola J.¹,Johnson Trevor¹,Dousson Cyril B.¹,Hill George B.¹,Perkins David¹,Hatter Glenn¹,Wilkinson Robert W.¹,Wedge Stephen R.¹,Heaton Simon P.¹,Odedra Rajesh¹,Keen Nicholas J.¹,Crafter Claire¹,Brown Elaine¹,Thompson Katherine¹,Brightwell Stephen¹,Khatri Liz¹,Brady Madeleine C.¹,Kearney Sarah¹,McKillop David¹,Rhead Steve¹,Parry Tony¹,Green Stephen¹

Affiliation:

1. AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom, and AstraZeneca, Centre de Recherches, Parc Industriel, Pompelle, BP1050, Chemin de Vrilly, 51689 Reims Cedex2, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061335f

Reference28 articles.

1. Aurora-kinase inhibitors as anticancer agents

2. Aurora kinases: shining lights on the therapeutic horizon?

3. Aurora A and B kinases as targets for cancer: will they be selective for tumors?

4. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Cited by 253 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes;eLife;2024-08-02

2. Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes;2024-05-01

3. Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells;European Journal of Medicinal Chemistry;2024-03

4. Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy;Medicinal Research Reviews;2023-11-20

5. Selective targeting of Aurora kinase B over A: Uncovering the structural basis for inhibitor specificity through molecular dynamics simulations;Journal of Molecular Structure;2023-11