Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Author:

Fais Stefano1,O’Driscoll Lorraine2,Borras Francesc E.3,Buzas Edit4,Camussi Giovanni5,Cappello Francesco6,Carvalho Joana,Cordeiro da Silva Anabela78,Del Portillo Hernando910,El Andaloussi Samir1112,Ficko Trček Tanja13,Furlan Roberto14,Hendrix An15,Gursel Ihsan16,Kralj-Iglic Veronika17,Kaeffer Bertrand18,Kosanovic Maja19,Lekka Marilena E.20,Lipps Georg21,Logozzi Mariantonia1,Marcilla Antonio,Sammar Marei22,Llorente Alicia23,Nazarenko Irina24,Oliveira Carla25,Pocsfalvi Gabriella26,Rajendran Lawrence27,Raposo Graça28,Rohde Eva2930,Siljander Pia,van Niel Guillaume28,Vasconcelos M. Helena7,Yáñez-Mó María31,Yliperttula Marjo L.,Zarovni Natasa32,Zavec Apolonija Bedina33,Giebel Bernd34

Affiliation:

1. Anti-Tumor Drugs Section, Department of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), 00161 Rome, Italy

2. School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

3. IVECAT-Group, Germans Trias i Pujol Research Institute (IGTP), and Nephrology Service, Germans Trias i Pujol University Hospital, Campus Can Ruti, 08916 Badalona, Spain

4. Department of Genetics, Cell- and Immunobiology, Semmelweis University, 1085 Budapest, Hungary

5. Molecular Biotechnology Center, Department of Medical Sciences, University of Turin, 8 Turin, Italy

6. Human Anatomy Section, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, and Euro-Mediterranean Institute of Science and Technology, 90133 Palermo, Italy

7. Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

8. Institute for Molecular and Cell Biology, Rua Campo Alegre, 4150-180 Porto, Portugal

9. ICREA at Barcelona Centre for International Health Research (CRESIB), Hospital Clínic de Universitat de Barcelona, 08036 Barcelona, Spain

10. ICREA at Institut d’Investigació Germans Trias i Pujol (IGTP), 08916 Badalona, Spain

11. Department of Laboratory Medicine, Karolinska Institutet, 17177 Stockholm, Sweden

12. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX13QX, United Kingdom

13. Sandoz Biopharmaceuticals−Lek Pharmaceuticals d.d., Mengeš, Slovenia

14. Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy

15. Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, 9000 Gent, Belgium

16. Science Faculty, Molecular Biology and Genetics Department, THORLAB- Therapeutic Oligonucleotide Research Lab, Bilkent University, 06800 Bilkent, Turkey

17. Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, 1000 Ljubljana, Slovenia

18. UMR-1280, INRA, and University of Nantes, 44300 Nantes, France

19. Department of Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy, INEP, Univeristy of Belgrade, 11000 Belgrade, Serbia

20. Chemistry Department, University of Ioannina, 45110 Ioannina, Greece

21. University of Applied Sciences and Arts Northwestern Switzerland, Gründenstrasse 40, 4132 Muttenz, Switzerland

22. Prof. Ephraim Katzir Department of Biotechnology Engineering, ORT Braude College, Karmiel 2161002, Israel

23. Dept. of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital−The Norwegian Radium Hospital, 0379 Oslo, Norway

24. Institute for Environmental Health Sciences and Hospital Infection Control, Medical Center University of Freiburg, 79106 Freiburg am Breisgau, Germany

25. Department of Pathology and Oncology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

26. Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, 80131 Naples, Italy

27. Systems and Cell Biology of Neurodegeneration, University of Zurich, 8006 Zurich, Switzerland

28. Institut Curie, PSL Research University, UMR144, Centre de Recherche, 26 rue d’ULM, and Centre National de la Recherche Scientifique, UMR144, 75231 Paris, France

29. Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), 5020 Salzburg, Austria

30. Department of Blood Group Serology and Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), 5020 Salzburg, Austria

31. Unidad de Investigación, Hospital Sta Cristina, IIS-IP, Departamento Biología Molecular/CBM-SO, UAM, 28009 Madrid, Spain

32. Exosomics Siena SpA, 53100 Siena, Italy

33. Laboratory for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia

34. Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

Reference156 articles.

1. ftp://ftp.cordis.europa.eu/pub/etp/docs/swd-2013-strategy-etp-2020_en.pdf(Accessed December 21, 2015) .

2. http://www.etp-nanomedicine.eu/public/press-documents/publications/etpn-publications/etpn-white-paper-H2020(Accessed December 21, 2015) .

3. ftp://ftp.cordis.europa.eu/pub/nanotechnology/docs/nanomedicine_bat_en.pdf(Accessed December 21, 2015) .

4. Biological properties of extracellular vesicles and their physiological functions

5. Exosomes: Small vesicles participating in intercellular communication

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