Nanoclustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity

Author:

Ma Yinchu12ORCID,Zhao Yangyang2,Bejjanki Naveen Kumar2,Tang Xinfeng2,Jiang Wei2ORCID,Dou Jiaxiang2,Khan Malik Ihsanullah2,Wang Qin2,Xia Jinxing3,Liu Hang4,You Ye-Zi4ORCID,Zhang Guoqing2ORCID,Wang Yucai12ORCID,Wang Jun5

Affiliation:

1. Intelligent Nanomedicine Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China

2. Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China

3. The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

4. Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230027, China

5. School of Biomedical Science and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 510006, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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