Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Author:

Zinger Assaf1ORCID,Koren Lilach1,Adir Omer1,Poley Maria1,Alyan Mohammed1,Yaari Zvi1,Noor Nadav2,Krinsky Nitzan1,Simon Assaf1,Gibori Hadas3,Krayem Majd1,Mumblat Yelena1,Kasten Shira1,Ofir Sivan1,Fridman Eran4,Milman Neta4,Lübtow Michael M.5,Liba Lior6,Shklover Jeny1,Shainsky-Roitman Janna1,Binenbaum Yoav4,Hershkovitz Dov7,Gil Ziv4,Dvir Tal2ORCID,Luxenhofer Robert5ORCID,Satchi-Fainaro Ronit3,Schroeder Avi1ORCID

Affiliation:

1. Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion−Israel Institute of Technology, Haifa 3200003, Israel

2. The School for Molecular Cell Biology and Biotechnology and the Department of Materials Science and Engineering, Tel Aviv University, Tel Aviv 6997800, Israel

3. Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997800, Israel

4. Department of Otolaryngology Head and Neck Surgery, Rambam Healthcare Campus, Technion−Israel Institute of Technology, Haifa 3200000, Israel

5. Functional Polymer Materials, Lehrstuhl für Chemische Technologie der Materialsynthese, Julius-Maximilians-Universität Würzburg, Röntgenring 11, Würzburg 97070, Germany

6. The Ruth and Bruce Rappaport Faculty of Medicine, Technion−Israel Institute of Technology, Haifa 3200003, Israel

7. Department of Pathology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997800, Israel

Funder

Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of Technology

Israel Cancer Association

Technion-Israel Institute of Technology

Israel Science Foundation

German-Israeli Foundation for Scientific Research and Development

Rothschild Caesarea Foundation

Ministry of Science and Technology, Israel

Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology

H2020 European Research Council

Seventh Framework Programme

Technion Integrated Cancer Center, Technion-Israel Institute of Technology

Ministry of Economy of Israel

Mallat Family Foundation

Phospholipid Research Center

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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