Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

Author:

Luo Guanghong12,Li Xing3,Lin Jihui14,Ge Gao5,Fang Jiangli6,Song Wangze7,Xiao Gary Guishan87,Zhang Bo19,Peng Xiaojun10,Duo Yanhong2611ORCID,Tang Ben Zhong12

Affiliation:

1. School of Medicine, The 2nd Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong 518172, P.R. China

2. Department of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong China

3. School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China

4. School of Nursing, Southwest Medical University, Luzhou, Sichuan 646000, China

5. Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China

6. Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, 171 77, Sweden

7. State Key Laboratory of Fine Chemicals, Department of Pharmacology, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China

8. Research Center for Cancer Metabolism, College of Pharmacology, Shenzhen University of Technology, Chinese Academy of Sciences, Shenzhen, 518118, China

9. Department of Neurosurgery, The Shenzhen Luohu Hospital Group, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518001, China

10. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China

11. Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong China

12. Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen. Shenzhen 518172, Guangdong China

Funder

Science, Technology and Innovation Commission of Shenzhen Municipality

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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