Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study-Reference-Cited by-同舟云学术

Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study

Published:2011-03-28 Issue:8 Volume:54 Page:2610-2626
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Radi Marco¹,Dreassi Elena¹,Brullo Chiara²,Crespan Emmanuele³,Tintori Cristina¹,Bernardo Vincenzo¹,Valoti Massimo⁴,Zamperini Claudio¹,Daigl Henry¹,Musumeci Francesca²,Carraro Fabio⁵,Naldini Antonella⁵,Filippi Irene⁵,Maga Giovanni³,Schenone Silvia²,Botta Maurizio¹⁶

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico, University of Siena,Via Alcide de Gasperi 2, I-53100 Siena, Italy

2. Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV 3, I-16132 Genova, Italy

3. Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, I-27100 Pavia, Italy

4. Dipartimento di Neuroscienze, University of Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy

5. Dipartimento di Fisiologia, Sezione di Neuroimmunofisiologia, University of Siena, Via Aldo Moro, I-53100 Siena, Italy

6. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1012819

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