Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant-Reference-Cited by-同舟云学术

Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant

Published:2010-06-01 Issue:12 Volume:53 Page:4701-4719
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Wei-Sheng¹,Metcalf Chester A.¹,Sundaramoorthi Raji¹,Wang Yihan¹,Zou Dong¹,Thomas R. Mathew¹,Zhu Xiaotian¹,Cai Lisi¹,Wen David¹,Liu Shuangying¹,Romero Jan¹,Qi Jiwei¹,Chen Ingrid¹,Banda Geetha¹,Lentini Scott P.¹,Das Sasmita¹,Xu Qihong¹,Keats Jeff¹,Wang Frank¹,Wardwell Scott¹,Ning Yaoyu¹,Snodgrass Joseph T.¹,Broudy Marc I.¹,Russian Karin¹,Zhou Tianjun¹,Commodore Lois¹,Narasimhan Narayana I.¹,Mohemmad Qurish K.¹,Iuliucci John¹,Rivera Victor M.¹,Dalgarno David C.¹,Sawyer Tomi K.¹,Clackson Tim¹,Shakespeare William C.¹

Affiliation:

1. ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100395q

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