Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
Author:
Affiliation:
1. Departments of Medicinal Chemistry, Cheminformatics, Computational Analytical and Structural Sciences, and Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, 709 Swedeland Road, P. O. Box 1539, King of Prussia, Pennsylvania 19406-0939
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm020017n
Reference33 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2. Drug-like properties and the causes of poor solubility and poor permeability
3. Design principles for orally bioavailable drugs
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