Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Author:

Sarott Roman C.1ORCID,You Inchul1,Li Yen-Der234,Toenjes Sean T.1ORCID,Donovan Katherine A.56ORCID,Seo Pooreum1,Ordonez Martha57,Byun Woong Sub1,Hassan Muhammad Murtaza1,Wachter Franziska567,Chouchani Edward T.58,Słabicki Mikołaj34,Fischer Eric S.56ORCID,Ebert Benjamin L.349,Hinshaw Stephen M.1ORCID,Gray Nathanael S.1ORCID

Affiliation:

1. Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States

2. Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, United States

3. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

4. Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, United States

5. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

6. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States

7. Department of Pediatrics, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School, Harvard University, Boston, Massachusetts 02215, United States

8. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States

9. Howard Hughes Medical Institute, Boston, Massachusetts 02115, United States

Funder

Howard Hughes Medical Institute

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Stanford Cancer Institute

National Institutes of Health

Mark Foundation For Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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