In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121-Reference-Cited by-同舟云学术

In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121

Published:2023-11-08 Issue:46 Volume:145 Page:25120-25133
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nguyen Romie C.¹,Davis Ian¹^ORCID,Dasgupta Medhanjali²,Wang Yifan¹,Simon Philipp S.²^ORCID,Butryn Agata³⁴^ORCID,Makita Hiroki²,Bogacz Isabel²^ORCID,Dornevil Kednerlin¹,Aller Pierre³⁴^ORCID,Bhowmick Asmit²^ORCID,Chatterjee Ruchira²,Kim In-Sik²,Zhou Tiankun³⁴,Mendez Derek²,Paley Daniel W.²,Fuller Franklin⁵,Alonso Mori Roberto⁵^ORCID,Batyuk Alexander⁵^ORCID,Sauter Nicholas K.²^ORCID,Brewster Aaron S.²^ORCID,Orville Allen M.³⁴^ORCID,Yachandra Vittal K.²^ORCID,Yano Junko²^ORCID,Kern Jan F.²,Liu Aimin¹^ORCID

Affiliation:

1. Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States

2. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

3. Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom

4. Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA, United Kingdom

5. LCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States

Funder

Royal Society

Welch Foundation

Wellcome Trust

National Institute of General Medical Sciences

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c04991

Reference74 articles.

1. Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins

2. Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes

3. Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

4. Hydroperoxoferric heme intermediate as a second electrophilic oxidant in cytochrome P450-catalyzed reactions

5. Unveiling the crucial intermediates in androgen production

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