Molecular Dynamics and Free Energy Studies on the Wild-type and Double Mutant HIV-1 Protease Complexed with Amprenavir and Two Amprenavir-Related Inhibitors: Mechanism for Binding and Drug Resistance-Reference-Cited by-同舟云学术

Molecular Dynamics and Free Energy Studies on the Wild-type and Double Mutant HIV-1 Protease Complexed with Amprenavir and Two Amprenavir-Related Inhibitors: Mechanism for Binding and Drug Resistance

Published:2007-02-15 Issue:6 Volume:50 Page:1177-1188
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hou Tingjun¹,Yu Ron¹

Affiliation:

1. Center for Theoretical Biological Physics, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0319

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0609162

Reference59 articles.

1. Rational Approach to AIDS Drug Design Through Structural Biology

2. Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

3. Substrate Shape Determines Specificity of Recognition for HIV-1 Protease

4. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

5. Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

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