Synthesis and Evaluation of [<sup>11</sup>C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis-Reference-Cited by-同舟云学术

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Synthesis and Evaluation of [¹¹C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis

Published:2023-02-03 Issue:3 Volume:20 Page:1709-1716
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ismailani Uzair S.¹²,Buchler Ariel²³,MacMullin Nicole²,Abdirahman Faduma²³,Adi Myriam²³^ORCID,Rotstein Benjamin H.¹²³^ORCID

Affiliation:

1. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada

2. University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada

3. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada

Funder

Canada Foundation for Innovation

Institute of Circulatory and Respiratory Health

Natural Sciences and Engineering Research Council of Canada

Ministry of Research and Innovation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00915

Reference45 articles.

1. Atherosclerosis

2. Atherosclerosis

3. Rapid Progression of Coronary Atherosclerosis: A Review

4. Role of NLRP3 Inflammasomes in Atherosclerosis

5. Inflammasomes: a preclinical assessment of targeting in atherosclerosis

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1. Structural Insight into the Binding Pattern and Interaction Mechanism of Antagonist MCC950 and Agonist BMS986299 with NLRP3 by Molecular Dynamics Simulation;Current Computer-Aided Drug Design;2024-05-24

2. Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a rat model of heart failure;Anais da Academia Brasileira de Ciências;2024

3. Radiosynthesis of [11C]MNS for PET imaging of NLRP3 inflammasome with [11C]nitromethane in one-pot and its evaluation in rat brains;Journal of Radioanalytical and Nuclear Chemistry;2023-10-04

4. Biological Applications of Autoradiography: Present and Future;PROG BIOCHEM BIOPHYS;2023

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