Investigating the Role of the Reduced Solubility of the Pirfenidone–Fumaric Acid Cocrystal in Sustaining the Release Rate from Its Tablet Dosage Form by Conducting Comparative Bioavailability Study in Healthy Human Volunteers

Author:

Kumari Nimmy1,Roy Parag1ORCID,Roy Sukanta23,Parmar Prashantkumar K.4,Chakraborty Soumalya4,Das Sourav23,Pandey Noopur1ORCID,Bose Anirbandeep2,Bansal Arvind Kumar4ORCID,Ghosh Animesh1ORCID

Affiliation:

1. Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India

2. Bioequivalence Study Center, TAAB Biostudy Services, Ibrahimpore Road, Kolkata 700032, India

3. School of Pharmacy, The Neotia University, Sarisha 743368, West Bengal, India

4. Solid State Pharmaceutics Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S Nagar, Mohali 160062, Punjab, India

Funder

All India Council for Technical Education

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference73 articles.

1. Idiopathic pulmonary fibrosis

2. Pharmacokinetic evaluation of two pirfenidone formulations in patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis

3. Idiopathic pulmonary fibrosis

4. PIRFENEX Tablets (Pirfenidone), January 21, 2020. https://ciplamed.com/content/pirfenex-tablets.

5. Baucom, M. IPF: Statistics, Facts, and You, February 7, 2020. https://www.healthline.com/health/managing-idiopathic-pulmonary-fibrosis/ipf-facts (last accessed 11.03.2022).

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