Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid To Eradicate Cancer Stem-like Cells

Author:

Khan Thahomina1,Igarashi Kazunori12,Tanabe Ami1,Miyazawa Taiki3,Fukushima Shigeto4,Miura Yutaka5,Matsumoto Yu2,Yamasoba Tatsuya2,Matsumoto Akira36ORCID,Cabral Horacio1ORCID,Kataoka Kazunori47ORCID

Affiliation:

1. Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Department of Otorhinolaryngology Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

3. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

4. Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan

5. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan

6. Kanagawa Institute of Industrial Science and Technology, Kawasaki 213-0012, Japan

7. Institute for Future Initiatives, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Funder

Japan Agency for Medical Research and Development

Center of Innovation Program

Asahi Glass Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Biochemistry, medical,Biomedical Engineering,General Chemistry,Biomaterials

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