Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis-Reference-Cited by-同舟云学术

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Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis

Published:2021-11-24 Issue:12 Volume:1 Page:2361-2376
ISSN:2691-3704
Container-title:JACS Au
language:en
Short-container-title:JACS Au

Author:

Gilon Chaim¹,Klazas Michal,Lahiani Adi,Schumacher-Klinger Adi,Merzbach Shira,Naoum Johnny N.¹,Ovadia Haim,Rubin Limor,Cornell-Kennon Susan²,Schaefer Erik M.²,Katzhendler Jehoshua,Marcinkiewicz Cezary³,Hoffman Amnon^ORCID,Lazarovici Philip¹^ORCID

Affiliation:

1. Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

2. AssayQuant Technologies, Inc., 260 Cedar Hill Street, Marlboro, Massachusetts 01752, United States

3. Department of Bioengineering, College of Engineering, Temple University, Philadelphia, Pennsylvania 19122, United States

Funder

Israel Innovation Authority

Publisher

American Chemical Society (ACS)

Subject

General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jacsau.1c00496

Reference52 articles.

1. Integrins: Versatility, modulation, and signaling in cell adhesion

2. Integrins as therapeutic targets

3. α4β7 integrin inhibitors: a patent review

4. The newcomer in the integrin family: Integrin α9 in biology and cancer

5. Regulation of cell migration by α4 and α9 integrins

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