Dissecting the Molecular Mechanisms of the Co-Aggregation of Aβ40 and Aβ42 Peptides: A REMD Simulation Study

Author:

Li Xuhua12,Yang Zhiwei1ORCID,Chen Yujie2,Zhang Shengli1ORCID,Wei Guanghong2ORCID,Zhang Lei1ORCID

Affiliation:

1. MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi’an Jiaotong University, Xi’an 710049, China

2. State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (Ministry of Education), and Department of Physics, Fudan University, 2005 Songhu Road, Shanghai 200438, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Reference84 articles.

1. Alzheimer's disease

2. Gauthier, S.; Webster, C.; Servaes, S.; Morais, J. A.; Rosa-Neto, P. World Alzheimer’s report 2022: Life after diagnosis: Navigating treatment, care and support; Alzheimer’s Disease International: London, England, 2022.

3. Aβ42 and Aβ40: similarities and differences

4. Regulation of APP cleavage by α-, β- and γ-secretases

5. The Profile of Soluble Amyloid β Protein in Cultured Cell Media

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