Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication-Reference-Cited by-同舟云学术

Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Published:2004-09-15 Issue:21 Volume:47 Page:5284-5297
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Eldrup Anne B.¹,Prhavc Marija¹,Brooks Jennifer¹,Bhat Balkrishen¹,Prakash Thazha P.¹,Song Quanlai¹,Bera Sanjib¹,Bhat Neelima¹,Dande Prasad¹,Cook P. Dan¹,Bennett C. Frank¹,Carroll Steven S.¹,Ball Richard G.¹,Bosserman Michele¹,Burlein Christine¹,Colwell Lawrence F.¹,Fay John F.¹,Flores Osvaldo A.¹,Getty Krista¹,LaFemina Robert L.¹,Leone Joseph¹,MacCoss Malcolm¹,McMasters Daniel R.¹,Tomassini Joanne E.¹,von Langen Derek¹,Wolanski Bohdan¹,Olsen David B.¹

Affiliation:

1. Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, Department of Biological Chemistry, Merck Research Laboratories, P.O Box 4, West Point, Pennslyvania 19486, and Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040068f

Reference26 articles.

1. Hepatitis C Virus NS5B Protein Is a Membrane-Associated Phosphoprotein with a Predominantly Perinuclear Localization

2. Structure and organization of the hepatitis C virus genome isolated from human carriers

3. Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

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