2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor-Reference-Cited by-同舟云学术

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor

Published:2006-10-24 Issue:23 Volume:49 Page:6819-6832
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Das Jagabandhu¹,Chen Ping¹,Norris Derek¹,Padmanabha Ramesh¹,Lin James¹,Moquin Robert V.¹,Shen Zhongqi¹,Cook Lynda S.¹,Doweyko Arthur M.¹,Pitt Sidney¹,Pang Suhong¹,Shen Ding Ren¹,Fang Qiong¹,de Fex Henry F.¹,McIntyre Kim W.¹,Shuster David J.¹,Gillooly Kathleen M.¹,Behnia Kamelia¹,Schieven Gary L.¹,Wityak John¹,Barrish Joel C.¹

Affiliation:

1. Bristol-Myers Squibb Pharmaceutical Research Institute, Post Office Box 4000, Princeton, New Jersey 08543-4000, and Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060727j

Reference44 articles.

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2. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

3. Signal transduction by lymphocyte antigen receptors

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