1. The Walter and Eliza Hall Institute of Medical Research Biotechnology Centre, 4 Research Avenue, La Trobe R&D Park, Bundoora 3086, Australia, School of Chemistry, University of Melbourne, Victoria 3010, Australia, Pharmaceutical Institute, University of Kiel, 24118 Kiel, Germany, and Department of Medical Pharmacology and Toxicology, University of California, Davis, California 95616