Mapping Spatiotemporal Heterogeneity in Multifocal Breast Tumor Progression by Noninvasive Ultrasound Elastography-Guided Mass Spectrometry Imaging Strategy

Author:

Zhou Peng12,Xiao Yu3,Zhou Xin1,Fang Jinghui2,Zhang Jingwen2,Liu Jianjun4,Guo Ling5,Zhang Jiuhong4,Zhang Ning6ORCID,Chen Ke7,Zhao Chao1289ORCID

Affiliation:

1. Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

2. Department of Ultrasound, First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen Second People’s Hospital, Shenzhen 518009, China

3. Department of Thyroid and Breast department, First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518009, China

4. Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, 518054, Shenzhen, China

5. Shenzhen Key Laboratory of Epigenetics and Precision Medicine for Cancers, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academic of Medical Sciences & Peking Union Medical College, Shenzhen 518172, China

6. College of Chemistry and Chemical Engineering, Dezhou University, Dezhou 253026, Shandong, China

7. Key Laboratory of Resources Conversion and Pollution Control of the State Ethnic Affairs Commission, College of Resources and Environmental Science, South-Central Minzu University, Wuhan 430074, China

8. Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

9. University of Chinese Academy of Sciences, Beijing 100049, China

Funder

National Key Research and Development Program of China

Shenzhen Fundamental Research Program

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Special Support Program for Training High-Level Talents in Guangdong

Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression

Sustainable Development Program of Shenzhen

Guangdong Province Zhu Jiang Talents Plan

Shenzhen Key Medical Discipline Construction Fund

Shenzhen Second People?s Hospital

Publisher

American Chemical Society (ACS)

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