1. Department of Chemistry, Durham University, Durham DH1 3LE, U.K.
2. Early Product Development and Manufacturing, Pharmaceutical Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83, Mölndal, Sweden
3. School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K.
4. AstraZeneca, Macclesfield SK10 2NA, U.K.
5. School of Medicine, Pharmacy and Health, Durham University, Durham DH1 3LE, U.K.
6. Chemistry, School of Natural and Environmental Sciences, Newcastle University Newcastle upon Tyne, NE1 7RU, U.K.