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A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library

Published:2007-04-21 Issue:10 Volume:50 Page:2385-2390
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Feng Brian Y.¹,Simeonov Anton¹,Jadhav Ajit¹,Babaoglu Kerim¹,Inglese James¹,Shoichet Brian K.¹,Austin Christopher P.¹

Affiliation:

1. Department of Pharmaceutical Chemistry & Graduate Group in Chemistry and Chemical Biology, 1700 4th Street, University of California San Francisco, San Francisco, California 94158-2330, and NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-3370

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061317y

Reference31 articles.

1. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

2. Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

3. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

4. Nonleadlikeness and leadlikeness in biochemical screening

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