Application of CoMFA and CoMSIA 3D-QSAR and Docking Studies in Optimization of Mercaptobenzenesulfonamides as HIV-1 Integrase Inhibitors

Author:

Kuo Chih-Ling1,Assefa Haregewein1,Kamath Shantaram1,Brzozowski Zdzialaw1,Slawinski Jaroslaw1,Saczewski Franciszek1,Buolamwini John K.1,Neamati Nouri1

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, PSC 304, Los Angeles, California 90089, Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, 847 Monroe Avenue Suite 327, Memphis, Tennessee 38163, and Department of Chemical Technology of Drugs, Medical University of Gdansk, 80-416 Gdansk, Poland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference34 articles.

1. Brown, P. O.Integration; Cold Spring Harbor Press:  Cold Spring Harbor, NY, 1999.

2. Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga

3. Small-Molecule HIV-1 Integrase Inhibitors: the 2001-2002 Update

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