Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5─Chemoenzymatic Diastereoselective Fluorination/DKR-Reference-Cited by-同舟云学术

Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5─Chemoenzymatic Diastereoselective Fluorination/DKR

Published:2024-02-07 Issue:2 Volume:28 Page:441-450
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

McCann Scott D.¹^ORCID,Dubina Sean H.¹^ORCID,Kosjek Birgit¹,Alwedi Embarek¹^ORCID,Behre Taylor¹^ORCID,Burgess Samantha A.²^ORCID,Dal Poggetto Guilherme²^ORCID,DiRocco Daniel A.¹^ORCID,Hartmanshenn Clara¹,McMullen Jonathan P.¹^ORCID,Padivitage Nilusha²,Sun Alexandra C.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00421

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3. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

4. Manufacturing Process Development for Belzutifan, Part 1: A Concise Synthesis of the Indanone Starting Material

5. Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

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