A Manufacturing Process to an Intermediate in the Synthesis of Acalabrutinib-Reference-Cited by-同舟云学术

A Manufacturing Process to an Intermediate in the Synthesis of Acalabrutinib

Published:2018-10-01 Issue:10 Volume:22 Page:1458-1460
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chen Bo¹,Golden Michael²^ORCID,Li Zhonglian¹,Xu Liwen¹,Xu Zhaofu¹,Yao Xiaolong¹

Affiliation:

1. Changzhou SynTheAll Pharmaceutical Co., Ltd., No. 589, North Yulong Road, Chunjiang Town, Xinbei District, Changzhou, 213127 Jiangsu, China

2. Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00287

Reference5 articles.

1. Barf, T.; Jans, C.; de Man, A.; Oubrie, A.; Raaijmakers, H.; Rewinkel, J.; Sterrenburg, J.G.; Wijkmans, J. 4-Imidazopyridazin-1-yl-benzamides and 4-Imidazotriazin-1-yl-benzamides as BTK Inhibitors. WO2013010868, 2013.

2. Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

3. A New Route to 2,3-Disubstituted Pyrazines; Regioselective Metalation of Chloropyrazine

4. Catalytic Asymmetric Synthesis of tert-Butanesulfinamide. Application to the Asymmetric Synthesis of Amines

5. Mao, Y.; Mulvihill, K.; Rechka, J.; Tavares-Greco, P. Preparation of C-Pyrazine-Methylamines. US2012/0041202, 2012.

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