Proprietary Synthesis of the C27–C35 Fragment of Eribulin and Its Elaboration toward the C14–C35 Subunit

Author:

Kim U Bin1,Samala Srinivas1,Jung Jaehun1,Song Juyoung1,Lee Kee-Young1,Oh Chang-Young1,Shin Hyunik1ORCID

Affiliation:

1. R&D Center, YS Life Science Co., Ltd., Innoplex-2-dong, 306, Sinwon-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16675, Republic of Korea

Funder

Ministry of Trade, Industry and Energy

Publisher

American Chemical Society (ACS)

Reference27 articles.

1. Natural products in drug discovery: advances and opportunities

2. Systematic review of Real-World effectiveness of eribulin for locally advanced or metastatic breast cancer

3. Halichondrins - antitumor polyether macrolides from a marine sponge

4. From micrograms to grams: scale-up synthesis of eribulin mesylate

5. Littlefield Bruce, A.; Palme, M.; Seletsky Boris, M.; Towle Murray, J.; Yu Melvin, J.; Zheng, W. Macrocyclic Analogs and Methods of Their Use and Preparation. U.S. Patent US6214865B1, 2001.

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