Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction-Reference-Cited by-同舟云学术

Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction

Published:2023-03-21 Issue:4 Volume:27 Page:763-774
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Armstrong Brittany M.¹^ORCID,Behre Taylor¹^ORCID,Turnbull Ben W. H.¹^ORCID,Bishara Daniel¹,Hartmanshenn Clara¹,McCarthy Erin²,Whittington Michael¹,Ji Yining¹^ORCID,Jenks Anna¹,Desmond Richard¹,Muzzio Daniel J.¹,Corry James¹,Zhao Ralph¹^ORCID,Kuhl Nadine¹^ORCID,Chung Cheol K.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00018

Reference14 articles.

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2. The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation

3. Chen, Y., Corry, J.; Desmond, R.; Di Maso, M. J.; Forstater, J. H.; Kuethe, J. T.; Kuhl, N.; Larson, R.; Levesque, F.; Narsimhan, K.; Otte, D.; Prier, C. K.; Shevlin, M.; Sirota, E.; Tan, L.; Thaisrivongs, D. A.; Turnbull, B. W. H.; Wang, Z.; Xiao, K. Synthesis of BTK Inhibitors and Intermediates Thereof. WO 2022251404 A1, December 26th, 2022

4. Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

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