Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir-Reference-Cited by-同舟云学术

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Development of New Catalytic Asymmetric Routes toward a Cost-Driving Building Block of Nirmatrelvir

Published:2024-05-28 Issue:7 Volume:28 Page:2743-2754
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Szpera Robert¹^ORCID,Huang Shanjun¹^ORCID,Fenton Harriet A. M.¹^ORCID,Waddington William¹,Gymer Adam E. S.¹,Moses Ian B.¹,Buck Julia¹,Ingram Heather¹,Fussell Steven J.¹,Walton Robert¹,Shanahan Charles S.²,Aleshire Sarah L.²,Robey Juliana M. S.²,Kalmode Hanuman P.²^ORCID,Nuckols Michel C.²,Kalikinidi Nageswara R.³,Janganati Venumadhav³,Joyasawal Sipak³,Amarasekarage Chanaka M.³,Senanayake Chris H.³^ORCID,Gupton B. Frank²^ORCID

Affiliation:

1. Pfizer Worldwide Research and Development Discovery Park, Sandwich CT13 9NJ, U.K.

2. Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23298, United States

3. TCG GreenChem, Inc., Ewing, New Jersey 08628, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00109

Reference32 articles.

1. Nirmatrelvir Plus Ritonavir: First Approval

2. https://www.pfizer.com/news/press-release/press-release-detail/pfizer-receives-us-fda-emergency-use-authorization-novel.

3. https://www.fda.gov/media/155050/download.

4. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

5. Owen, D. R.; Pettersson, M. Y.; Reese, M. R.; Sammons, M. F.; Tuttle, J. B.; Verhoest, P. R.; Wei, L.; Yang, Q.; Yang, X. Nitrile-containing antiviral compounds, Patent WO2021250648A1, 2021.

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