The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future-Reference-Cited by-同舟云学术

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

Published:2019-05-07 Issue:6 Volume:23 Page:1213-1242
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Mennen Steven M.¹^ORCID,Alhambra Carolina²^ORCID,Allen C. Liana³,Barberis Mario²,Berritt Simon⁴^ORCID,Brandt Thomas A.⁵,Campbell Andrew D.⁶,Castañón Jesús²,Cherney Alan H.¹^ORCID,Christensen Melodie⁷^ORCID,Damon David B.⁵^ORCID,Eugenio de Diego J.²,García-Cerrada Susana²,García-Losada Pablo²^ORCID,Haro Rubén²,Janey Jacob⁸^ORCID,Leitch David C.³^ORCID,Li Ling³,Liu Fangfang⁹,Lobben Paul C.⁸,MacMillan David W. C.¹⁰^ORCID,Magano Javier⁵^ORCID,McInturff Emma⁵^ORCID,Monfette Sebastien⁵,Post Ronald J.¹¹,Schultz Danielle⁷^ORCID,Sitter Barbara J.⁵,Stevens Jason M.⁸^ORCID,Strambeanu Iulia I.³^ORCID,Twilton Jack¹⁰^ORCID,Wang Ke⁹,Zajac Matthew A.³^ORCID

Affiliation:

1. Drug Substance Technologies, Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

2. Centro de Investigación Lilly S. A., Avda. de la Industria 30, Alcobendas, Madrid 28108, Spain

3. API Chemistry, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

4. Internal Medicine, Applied Synthesis Technology, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

5. Process Chemistry, Chemical R&D, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

6. Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire SK10 2NA, United Kingdom

7. Process Research and Development, Merck & Co., Inc. Rahway, New Jersey 07065, United States

8. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08901, United States

9. Pharmaceutical Sciences, Pfizer Global Supply Statistics, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

10. Merck Center for Catalysis at Princeton University, Washington Road, Princeton, New Jersey 08544, United States

11. Engineering Group, Chemical R&D, Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00140

Reference100 articles.

1. High-Throughput Automation in Chemical Process Development

2. Practical High-Throughput Experimentation for Chemists

3. The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis

4. An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine

5. Selective functionalization of complex heterocycles via an automated strong base screening platform

Cited by 249 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Kappaphycus alvarezii as a renewable source of kappa-carrageenan and other cosmetic ingredients;International Journal of Biological Macromolecules;2024-03

2. Chemoinformatic Catalyst Selection Methods for the Optimization of Copper–Bis(oxazoline)-Mediated, Asymmetric, Vinylogous Mukaiyama Aldol Reactions;ACS Catalysis;2024-02-06

3. Covalent Phenanthroline‐Porphyrin Polymer for Aminocarbonylation through Electro/Thermocatalytic Tandem Processes: Extending Chemical Valorization of CO₂;Advanced Functional Materials;2024-02-04

4. Is a high-throughput experimental dataset large enough to accurately estimate a statistic?;Journal of the Mechanics and Physics of Solids;2024-02

5. A Pharma Perspective on Sustainability Advantages through adoption of Continuous Flow;Current Opinion in Green and Sustainable Chemistry;2024-02