MEPicides: α,β-unsaturated Fosmidomycin <i>N</i>-Acyl Analogs as Efficient Inhibitors of <i>Plasmodium falciparum</i> 1-Deoxy-<scp>d</scp>-xylulose-5-phosphate reductoisomerase-Reference-Cited by-同舟云学术

MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase

Published:2023-06-13 Issue:7 Volume:9 Page:1387-1395
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Wang Xu¹^ORCID,Edwards Rachel L.²,Ball Haley S.³^ORCID,Heidel Kenneth M.¹,Brothers Robert C.¹,Johnson Claire³,Haymond Amanda³,Girma Misgina³,Dailey Allyson³,Roma Jose Santinni⁴,Boshoff Helena I.⁴^ORCID,Osbourn Damon M.⁵^ORCID,Meyers Marvin J.⁵,Couch Robin D.³,Odom John Audrey R.²^ORCID,Dowd Cynthia S.¹^ORCID

Affiliation:

1. Department of Chemistry, George Washington University, Washington, District of Columbia 20052, United States

2. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States

3. Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States

4. Tuberculosis Research Section, LCIM, NIAID/NIH, Bethesda, Maryland 20892, United States

5. Department of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States

Funder

George Washington University

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00132

Reference29 articles.

1. World malaria report. 2022, https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022 (accessed May 13, 2023).

2. Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

3. Regulation of the mevalonate pathway

4. The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants†

5. Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake