Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis-Reference-Cited by-同舟云学术

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Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis

Published:2016-08-08 Issue:9 Volume:2 Page:616-626
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Gopal Pooja¹,Yee Michelle¹,Sarathy Jickky¹,Low Jian Liang¹,Sarathy Jansy P.²,Kaya Firat²,Dartois Véronique²,Gengenbacher Martin¹,Dick Thomas¹

Affiliation:

1. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore

2. Public Health Research Institute, Rutgers—New Jersey Medical School, Newark, New Jersey 07103, United States

Funder

National Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

http://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00070

Reference56 articles.

1. The action of antituberculosis drugs in short-course chemotherapy

2. New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

3. Mechanisms of Pyrazinamide Action and Resistance

4. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

5. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

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