Trimethoxybenzanilide-Based P-Glycoprotein Modulators: An Interesting Case of Lipophilicity Tuning by Intramolecular Hydrogen Bonding-Reference-Cited by-同舟云学术

Trimethoxybenzanilide-Based P-Glycoprotein Modulators: An Interesting Case of Lipophilicity Tuning by Intramolecular Hydrogen Bonding

Published:2014-08-05 Issue:15 Volume:57 Page:6403-6418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tardia Piero¹,Stefanachi Angela¹,Niso Mauro¹,Stolfa Diana Antonella¹,Mangiatordi Giuseppe Felice¹,Alberga Domenico²,Nicolotti Orazio¹,Lattanzi Gianluca²,Carotti Angelo¹,Leonetti Francesco¹,Perrone Roberto¹,Berardi Francesco¹,Azzariti Amalia³,Colabufo Nicola Antonio¹,Cellamare Saverio¹

Affiliation:

1. Dipartimento di Farmacia—Scienze del Farmaco, Università di Bari ”Aldo Moro”, Via Orabona 4, 70125 Bari, Italy

2. Dipartimento di Fisica, Università di Bari ”Aldo Moro”, INFN & TIRES, Via Amendola 173, 70126 Bari, Italy

3. Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco 65, 70124 Bari, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500697c

Reference44 articles.

1. Multidrug Resistance in Cancer

2. ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

3. ABC Pumps and Their Role in Active Drug Transport

4. Lipid Bilayer Properties Control Membrane Partitioning, Binding, and Transport of P-Glycoprotein Substrates

5. About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

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