Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

Author:

Li Kai1,Schurig-Briccio Lici A.2,Feng Xinxin1,Upadhyay Ashutosh3,Pujari Venugopal3,Lechartier Benoit4,Fontes Fabio L.3,Yang Hongliang3,Rao Guodong1,Zhu Wei5,Gulati Anmol1,No Joo Hwan6,Cintra Giovana6,Bogue Shannon2,Liu Yi-Liang5,Molohon Katie7,Orlean Peter7,Mitchell Douglas A.178,Freitas-Junior Lucio6,Ren Feifei9,Sun Hong9,Jiang Tong9,Li Yujie9,Guo Rey-Ting9,Cole Stewart T.4,Gennis Robert B.12,Crick Dean C.3,Oldfield Eric15

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States

2. Department of Biochemistry, University of Illinois at Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States

3. Department of Microbiology, Immunology and Pathology, Colorado State University, 200 West Lake Street, Fort Collins, Colorado 80523, United States

4. Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

5. Center for Biophysics and Computational Biology, University of Illinois at Urbana−Champaign, 607 South Mathews Avenue, Urbana, Illinois 61801, United States

6. Institut Pasteur Korea, Sampyeong-dong 696, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

7. Department of Microbiology, University of Illinois at Urbana−Champaign, 601 South Goodwin Avenue, Urbana, Illinois 61801, United States

8. Institute for Genomic Biology, University of Illinois at Urbana−Champaign, 1206 West Gregory Drive, Urbana, Illinois 61801, United States

9. Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

Funder

National Institutes of Health

American Heart Association

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference46 articles.

1. US Department of Health and Human Services Centers for Disease Control and Prevention, Antibiotic resistance threats in the United States 2013.http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf(accessedMarch 31, 2014).

2. World Health Organization, Global tuberculosis report (2013.http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656_eng.pdf?ua=1(accessedMarch 31, 2014).

3. Amphotericin primarily kills yeast by simply binding ergosterol

4. Combination therapies for combating antimicrobial resistance

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