1. Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1020, New Zealand, Ann Arbor Laboratories, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48106-1047, and La Jolla Laboratories, Pfizer Global Research and Development, 10646 Science Center Drive, La Jolla, California 92121