Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis

Author:

Kuo Ting-Hao,Lin Tzu-Hung,Yang Rong-Sen1,Kuo Sheng-Chu2,Fu Wen-Mei,Hung Hsin-Yi34

Affiliation:

1. Department of Orthopedics, College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan

2. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, 404, Taiwan

3. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, 404, Taiwan

4. School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference19 articles.

1. The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005–2008

2. Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005-2025

3. Cooper, C.; Cole, Z. A.; Holroyd, C. R.; Earl, S. C.; Harvey, N. C.; Dennison, E. M.; Melton, L. J.; Cummings, S. R.; Kanis, J. A.; IOF CSA Working Group on Fracture Epidemiology.Secular trends in the incidence of hip and other osteoporotic fractures.Osteoporosis Int. 2011, 22, 1277–1288.

4. Challenges in implementing and maintaining osteoporosis therapy

5. Vitamin B12–dependent taurine synthesis regulates growth and bone mass

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