Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor-Reference-Cited by-同舟云学术

Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor

Published:2013-06-28 Issue:13 Volume:56 Page:5247-5260
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shiao Hui-Yi¹,Coumar Mohane Selvaraj²,Chang Chun-Wei¹,Ke Yi-Yu¹,Chi Ya-Hui³,Chu Chang-Ying¹,Sun Hsu-Yi¹,Chen Chun-Hwa¹,Lin Wen-Hsing¹,Fung Ka-Shu¹,Kuo Po-Chu¹,Huang Chin-Ting¹,Chang Kai-Yen¹,Lu Cheng-Tai¹,Hsu John T. A.¹,Chen Chiung-Tong¹,Jiaang Weir-Torn¹,Chao Yu-Sheng¹,Hsieh Hsing-Pang¹

Affiliation:

1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, ROC

2. Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India

3. Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, ROC

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4006059

Reference33 articles.

1. Protein Kinase Inhibitors: Insights into Drug Design from Structure