Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)-Reference-Cited by-同舟云学术

Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

Published:2014-04-01 Issue:6 Volume:5 Page:700-705
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hu Essa¹²,Andrews Kristin¹²,Chmait Samer¹²,Zhao Xiaoning¹²,Davis Carl¹²,Miller Silke¹²,Hill Della Puppa Geraldine¹²,Dovlatyan Mary¹²,Chen Hang¹²,Lester-Zeiner Dianna¹²,Able Jessica¹²,Biorn Christopher¹²,Ma Ji¹²,Shi Jianxia¹²,Treanor James¹²,Allen Jennifer R.¹²

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Molecular Structure, §Department of Pharmacokinetics and Drug Metabolism, and ∥Department of Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 93012-1799, United States

2. Department of Molecular Structure and Characterization, ∇Department of Neuroscience, and ○Department of Pharmacokinetics and Drug Metabolism, Amgen, Inc., 1120 Veterans Boulevard, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml5000993

Reference10 articles.

1. Phosphodiesterases in the CNS: targets for drug development

2. Role of phosphodiesterases in neurological and psychiatric disease

3. PDE inhibitors in psychiatry–future options for dementia, depression and schizophrenia?

4. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs

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