Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist-Reference-Cited by-同舟云学术

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Published:2004-03-16 Issue:8 Volume:47 Page:1969-1986
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Chengde¹,Decker E. Radford¹,Blok Natalie¹,Bui Huong¹,You Tony J.¹,Wang Junmei¹,Bourgoyne Andree R.¹,Knowles Vippra¹,Berens Kurt L.¹,Holland George W.¹,Brock Tommy A.¹,Dixon Richard A. F.¹

Affiliation:

1. Encysive Pharmaceuticals Inc., 7000 Fannin, Houston, Texas 77030

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030528p

Reference49 articles.

1. Acute Endothelin A Receptor Blockade Causes Selective Pulmonary Vasodilation in Patients With Chronic Heart Failure

2. Clinical Efficacy of Sitaxsentan, an Endothelin-A Receptor Antagonist, in Patients With Pulmonary Arterial Hypertension

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