Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Published:2004-07-31 Issue:18 Volume:47 Page:4417-4426
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oost Thorsten K.¹,Sun Chaohong¹,Armstrong Robert C.¹,Al-Assaad Ali-Samer¹,Betz Stephen F.¹,Deckwerth Thomas L.¹,Ding Hong¹,Elmore Steven W.¹,Meadows Robert P.¹,Olejniczak Edward T.¹,Oleksijew Andrew¹,Oltersdorf Tilman¹,Rosenberg Saul H.¹,Shoemaker Alexander R.¹,Tomaselli Kevin J.¹,Zou Hua¹,Fesik Stephen W.¹

Affiliation:

1. Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, Idun Pharmaceuticals, 9380 Judicial Drive, San Diego, California 92121, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, California 92121, and Ferring Research Institute, 3550 General Atomics Court, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040037k

Reference30 articles.

1. IAP family proteins---suppressors of apoptosis

2. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

3. Mechanism of XIAP-Mediated Inhibition of Caspase-9

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