Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection-Reference-Cited by-同舟云学术

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Published:2015-02-10 Issue:4 Volume:58 Page:1862-1878
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Guangyi¹,Deval Jerome¹,Hong Jin¹,Dyatkina Natalia¹,Prhavc Marija¹,Taylor Joshua¹,Fung Amy¹,Jin Zhinan¹,Stevens Sarah K.¹,Serebryany Vladimir¹,Liu Jyanwei¹,Zhang Qingling¹,Tam Yuen¹,Chanda Sushmita M.¹,Smith David B.¹,Symons Julian A.¹,Blatt Lawrence M.¹,Beigelman Leo¹

Affiliation:

1. Alios BioPharma, Inc., 260 East Grand Avenue, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5017279

Reference39 articles.

1. Respiratory Syncytial Virus—A Comprehensive Review

2. Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

3. Respiratory syncytial virus prevention and therapy: Past, present, and future